Acquired deficiency of clotting factors: Difference between revisions

| OldDxArticle =Transfusion Coagulopathy| CurrentStatus = freshly automatically generated article

* Coagulation disorders in liver disease: The liver plays a central role in the clotting process, and acute and chronic liver diseases are invariably associated with coagulation disorders due to multiple causes: decreased synthesis of clotting and inhibitor factors, decreased clearance of activated factors, quantitative and qualitative platelet defects, hyperfibrinolysis, and accelerated intravascular coagulation.

* Vitamen K deficiency: Combined deficiency of vitamin K-dependent clotting factors II, VII, IX and X (and proteins C, S, and Z) is usually an acquired clinical problem, often resulting from liver disease, malabsorption, or warfarin overdose.

*Transfusion and dilutional coagulopathy:A massive transfusion of red blood cells (RBCs) may lead to a dilutional coagulopathy, as plasma-reduced RBCs contain neither coagulation factors nor platelets. Secondly, haemorrhage, as a consequence of delayed or inadequate perfusion, can result in disseminated intravascular coagulation. This causes consumption of platelets and coagulation factors and may account for the numerical distortion of clotting studies appearing out of proportion to the volume of blood transfused. Aggressive, expectant replacement of clotting factors with fresh frozen plasma (FFP), platelets and cryoprecipitate transfusions are required to prevent this coagulopathy becoming severe enough to make haemorrhage worse.

(put links to likely candidates coded with this one, eg. a cause for a trauma.)

== Related CCI Codes ==