Acute megakaryoblastic leukemia: Difference between revisions
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{{ICD10 category|Heme/immunology}}{{ICD10 category|Neoplastic}} | {{ICD10 category|Heme/immunology}}{{ICD10 category|Neoplastic}}{{ICD10 category|Leukemia}} | ||
== Additional Info == | == Additional Info == | ||
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*Diagnosis requires more than 20% Blasts in the marrow/ peripheral blood with more than 50% demonstrating megakaryocytic derivation by morphology, immunophenotypic or electron microscopic studies. | *Diagnosis requires more than 20% Blasts in the marrow/ peripheral blood with more than 50% demonstrating megakaryocytic derivation by morphology, immunophenotypic or electron microscopic studies. | ||
CAUSES: It is associated with GATA1, and risks are increased in individuals with Down syndrome. However, not all cases are associated with Down syndrome, and other genes can also be associated with AMKL. Another related gene is MKL1, which is also known as "MAL".[6] This gene is a cofactor of serum response factor. | CAUSES: It is associated with GATA1, and risks are increased in individuals with Down syndrome. However, not all cases are associated with Down syndrome, and other genes can also be associated with AMKL. Another related gene is MKL1, which is also known as "MAL".[6] This gene is a cofactor of serum response factor. | ||
== Alternate ICD10s to consider coding instead or in addition == | == Alternate ICD10s to consider coding instead or in addition == | ||
{{ListICD10Category | categoryName = Leukemia}} | |||
== Candidate [[Combined ICD10 codes]] == | == Candidate [[Combined ICD10 codes]] == | ||