View source for Acute megakaryoblastic leukemia

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{{ICD10 category|Heme/immunology}}{{ICD10 category|Neoplastic}}{{ICD10 category|Leukemia}} 

== Additional Info ==
*Acute megakaryoblastic leukemia (AMKL) is a form of leukemia where a majority of the blasts are megakaryoblastic.

*It is classified under AML-M7 category of the French-American-British classification.

*The latest WHO classification (2008, Lyon), classifies Acute Myeloid Leukemia into distinct subtypes, based on clinico-pathological and molecular features. Acute megakaryoblastic leukemia is placed under the AML-Not Otherwise Specified subcategory.

*Diagnosis requires more than 20% Blasts in the marrow/ peripheral blood with more than 50% demonstrating megakaryocytic derivation by morphology, immunophenotypic or electron microscopic studies.

CAUSES: It is associated with GATA1, and risks are increased in individuals with Down syndrome. However, not all cases are associated with Down syndrome, and other genes can also be associated with AMKL. Another related gene is MKL1, which is also known as "MAL".[6] This gene is a cofactor of serum response factor.

== Alternate ICD10s to consider coding instead or in addition ==
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== Candidate [[Combined ICD10 codes]] ==

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