Acute promyelocytic leukaemia (APL)
ICD10 Diagnosis | |
Dx: | Acute promyelocytic leukaemia (APL) |
ICD10 code: | C92.4 |
Pre-ICD10 counterpart: | none assigned |
Charlson/ALERT Scale: | Any malignancy, including lymphoma and leukemia, except of skin |
APACHE Como Component: | Immunocompromised |
APACHE Acute Component: | none |
Start Date: | |
Stop Date: | |
External ICD10 Documentation |
This diagnosis is a part of ICD10 collection.
Additional Info
- Acute promyelocytic leukemia (APML, APL) is a subtype of acute myeloid leukemia (AML), a cancer of the white blood cells.[1]
- In APL, there is an abnormal accumulation of immature granulocytes called promyelocytes. The disease is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARα or RARA) gene and is distinguished from other forms of AML by its responsiveness to all-trans retinoic acid (ATRA; also known as tretinoin) therapy.
- Acute promyelocytic leukemia was first characterized in 1957[2][3] by French and Norwegian physicians as a hyperacute fatal illness,[1] with a median survival time of less than a week.[4] Today, prognoses have drastically improved; 10-year survival rates are estimated to be approximately 77% according to one study
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