Myopathy, drug-induced

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ICD10 Diagnosis
Dx: Myopathy, drug-induced
ICD10 code: G72.0
Pre-ICD10 counterpart: Myopathy
Charlson/ALERT Scale: none
APACHE Como Component: none
APACHE Acute Component: none
Start Date:
Stop Date:
External ICD10 Documentation

This diagnosis is a part of ICD10 collection.

  • SMW
    • 2019-01-01
    • 2999-12-31
    • G72.0
  • Cargo

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Additional Info

incl paralytics, steroids, {sc:alcohol}

  • A drug-induced, or toxic, myopathy is defined as the acute or subacute manifestation of myopathic symptoms such as muscle weakness, myalgia, creatine kinase elevation, or myoglobinuria that can occur in patients without muscle disease when they are exposed to certain drugs.
  • Toxic myopathies are often a diagnosis of exclusion, as the differential diagnosis for muscle symptoms can be quite broad. Endocrine disorders such as hypothyroidism, hyperthyroidism, and hyperparathyroidism are common causes of elevated CK and muscle weakness and always should be considered when toxic myopathy is suspected. Similarly, muscular dystrophies such as limb girdle muscular dystrophy, dystrophinopathies, Becker’s muscular dystrophy, or Duchenne’s muscular dystrophy can also mimic symptoms of drug-induced myopathies. Metabolic disorders such as glycogen or lipid storage diseases, mitochondrial myopathies, and nutritional deficiencies can cause exercise intolerance, elevated CK, myalgias, or weakness. Inflammatory diseases such as polymyositis, dermatomyositis, or inclusion body myositis also should be considered and excluded through muscle biopsy, as these disorders have different therapeutic implications.
  • Steroid myopathy is usually an insidious disease process that causes weakness mainly to the proximal muscles of the upper and lower limbs and to the neck flexors

Guidelines for Acquired neuromuscular weakness

  • Many acutely ill (especially critically ill) patients develop/acquire weakness while in hospital
  • But, there are a variety of different causes of such weakness, including related to problems with nerves (neuropathies) and muscles (myopathies). While there are some ways to distinguish among these (e.g. use of EMG/NCV testing) this is almost never done because other than avoidance, there are no real treatments for any of these, i.e. they're all treated with rehabilitation.

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